RT Book, Section
A1 Hill, Ivor D.
A1 Caicedo, Ricardo A.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7037058
T1 Chapter 408. Disorders of Digestion and Absorption
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7037058
RD 2024/04/18
AB The  assimilation  of  ingested  nutrients  involves  a  complex  integrated  process  of  digestion  and  absorption  with  subsequent  transport  of  the  breakdown  products  across  the  intestinal  mucosa  into  the  systemic  circulation.  Normal  digestion  and  absorption  is  discussed  in  Chapter  381.  The  term  malabsorption  is  broadly  used  to  characterize  abnormalities  of  both  digestion  and  absorption.  The  schema  in  Table  408-1  lists  the  major  pathogenic  mechanisms  of  various  specific  malabsorptive  disorders  that  are  generally  due  to  disorders  in  luminal  digestion,  mucosal  function,  or  lymphatic  transport.  Malabsorption  may  involve  multiple  nutrients  (as  occurs  with  celiac  disease  or  pancreatic  insufficiency)  or  only  a  single  molecule  (as  found  in  isolated  glucose-galactose  malabsorption  or  vitamin  B12  malabsorption).  Defects  may  be  congenital,  with  onset  of  symptoms  shortly  after  birth,  or  acquired,  when  the  age  of  onset  of  symptoms  is  variable.