RT Book, Section
A1 Journeycake, Janna M.
A1 Yang, Janet
A1 Chan, Anthony K. C.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7039949
T1 Chapter 435. Normal and Abnormal Hemostasis
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7039949
RD 2024/04/20
AB The  hemostatic  mechanism  is  a  dynamic  system  that  maintains  the  fluidity  of  blood,  while  allowing  for  the  formation  of  blood  clots  to  prevent  bleeding  subsequent  to  blood  vessel  injury.  These  interrelated  components  consist  of  vessel  walls  (including  endothelial  cells),  platelets,  coagulation  factors,  inhibitors,  and  the  fibrinolytic  mechanism.  Perturbation  of  any  of  these  systems  can  lead  to  disease  states  that  are  thrombotic  or  hemorrhagic  in  nature.  This  chapter  discusses  the  normal  and  abnormal  hemostatic  system  in  children,  with  emphasis  on  disorders  involving  the  endothelium,  platelets,  and  defects  in  coagulation  and  fibrinolysis.