RT Book, Section
A1 Nachman, James B.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7042265
T1 Chapter 449. Acute Lymphoblastic Leukemia
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7042265
RD 2023/03/22
AB Acute  lymphoblastic  leukemia  (ALL)  is  the  most  common  childhood  malignancy,  accounting  for  almost  25%  of  cancer  diagnoses  seen  in  children  younger  than  age  15  years.  Patients  with  more  than  25%  lymphoid  blasts  in  the  bone  marrow  are  considered  to  have  leukemia  regardless  of  the  presence  of  extramedullary  disease.  Patients  who  have  an  extramedullary  lymphoid  mass  and  5%  to  25%  lymphoid  blasts  in  the  marrow  are  considered  to  have  lymphoblastic  lymphoma  with  marrow  involvement.  There  are  approximately  2400  new  cases  of  ALL  diagnosed  in  children  and  adolescents  less  than  20  years  of  age  each  year  in  the  United  States.1The  peak  incidence  of  ALL  is  in  the  2-  to  6-year-old  age  group.  The  incidence  of  ALL  appears  to  be  highest  in  Hispanic  children  and  lowest  in  African  American  children.2