RT Book, Section
A1 Hudson, Melissa M.
A1 Trippett, Tanya M.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7042638
T1 Chapter 452. Hodgkin Lymphoma
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7042638
RD 2024/04/23
AB Hodgkin  lymphoma  is  a  hematopoietic  malignancy  with  unique  epidemiologic  features  that  vary  depending  on  the  geographic  region  of  the  patient.  Genetic  and  environmental  contributions  to  the  pathogenesis  of  the  disease  are  not  completely  understood  and  represent  an  active  area  of  research.  Progression  of  Hodgkin  lymphoma  initially  occurs  along  functionally  contiguous  lymph  nodes.  If  untreated,  extranodal  involvement  eventually  results  from  hematogenous  dissemination  of  neoplastic  cells  to  the  liver,  lungs,  bones,  bone  marrow,  and  other  tissues.  The  most  common  clinical  presentation  is  one  of  painless  lymphadenopathy  previously  attributed  to  infectious  or  inflammatory  etiologies.  Other  signs  and  symptoms  vary  based  on  the  involved  nodal  sites  and  their  compression  of  adjacent  organs  and  tissues.  Cytokine  production  by  malignant  cells  results  in  constitutional  symptoms  including  anorexia,  pruritus,  weight  loss,  night  sweats,  and  fever  in  some  patients.