RT Book, Section
A1 Gorlick, Richard
A1 Meyers, Paul A.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7042696
T1 Chapter 453. Osteosarcoma
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7042696
RD 2024/04/24
AB Osteosarcoma  is  the  most  common  malignant  primary  bone  tumor  in  children  and  adolescents.Osteosarcoma’s  destruction  of  normal  bone  architecture  and  its  production  of  malignant  osteoid  can  permit  its  identification  from  skeletal  remains,  allowing  the  recognition  that  it  is  an  ancient  disease.  Among  the  earliest  malignant  bone  tumor  described  in  humans,  it  was  presumed  to  be  identified  in  the  humerus  of  a  male  Celt  from  800  to  600  BC.1  A  probable  osteosarcoma  dates  back  to  250  AD  in  the  pelvis  of  a  young  individual  from  Ancient  Egypt.  A  definite  osteosarcoma  with  a  classic  sunburst  appearance  was  found  in  the  remains  of  the  femur  of  a  Peruvian  from  approximately  1100  to  1200  AD.1  The  term  osteosarcoma  was  introduced  by  Alexis  Boyer  (1757–1833),  and  the  first  large  clinical-pathological  description  of  sarcomas  of  bone  was  performed  by  Samuel  Weissel  Gross  (1837–1889).2  In  this  description,  the  tendency  for  hematogenous  and  not  lymphatic  dissemination,  as  well  as  the  occurrence  of  skip  metastases,  led  to  the  suggestion  that  amputation  be  performed  at  a  distance  beyond  the  primary  lesion.2