RT Book, Section A1 Tomlinson, Gail E. A1 Katzenstein, Howard M. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 7043620 T1 Chapter 458. Malignant Liver Tumors T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=7043620 RD 2024/11/02 AB Liver tumors represent approximately 1% of all childhood cancers. There are approximately 100 to 150 new cases of liver cancer diagnosed in children each year in the United States.1 Hepatoblastoma is the most common malignant tumor of the liver and accounts for two thirds of all liver cancer in children.2 Hepatoblastoma occurs almost always in the very young child, with a mean age of onset of approximately 18 to 20 months and 95% of cases occurring before 5 years of age. The incidence of hepatoblastoma has approximately doubled over the past few decades.3 Hepatoblastoma is considered an embryonal tumor because histologically, tumor cells resemble cells seen in the developing liver.