RT Book, Section
A1 Egeler, Maarten
A1 Arceci, Robert J.
A1 Henter, Jan-Inge
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7044074
T1 Chapter 463. Histiocytic Disorders
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7044074
RD 2024/04/24
AB Under  the  term  histiocytoses,  we  consider  a  group  of  disorders  that  have  in  common  the  proliferation  of  cells  of  the  mononuclear  phagocytic  system  and  the  dendritic  cell  (DC)  system.  Normally,  histiocytes  (tissue  macrophages)  and  DCs  are  involved  in  immune  and  inflammatory  responses.  The  histiocytoses  are  each  characterized  by  localized  or  generalized  reactive  or  neoplastic  proliferation  of  cells  similar,  if  not  identical,  to  one  of  these  cell  types.  They  are  diagnosed  on  the  basis  of  characteristic  signs,  symptoms,  and  laboratory  findings  that,  in  combination  with  specific  histological  features,  satisfy  diagnostic  criteria.  In  the  case  of  Langerhans  cell  histiocytosis  (LCH),  the  proliferating  cell  is  the  Langerhans  cell,  and  in  hemophagocytic  lymphohistiocytosis  (HLH),  the  macrophage  accumulates.