RT Book, Section A1 Reiter, Edward O. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 7053055 T1 Chapter 524. Tall Stature T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=7053055 RD 2024/03/29 AB Most tall children are normal, and their stature is linked to genetic background and an optimal environment for growth. Tall stature is concerning only if a child’s tallness is inappropriate for parental height or when linear growth velocity accelerates inappropriately. A number of endocrine and nonendocrine disorders cause excessive linear growth during childhood and adolescence (Table 524-1). Endocrine causes of accelerated growth include growth hormone (GH) excess or acromegaly; thyrotoxicosis; excess androgenic hormones, as in congenital adrenal hyperplasia and virilizing tumors; and sexual precocity. The latter disorders are readily apparent on physical examination because of accompanying signs of androgen excess or sexual maturation. Adolescents with hypogonadotropic hypogonadism can also be tall and have a eunuchoid habitus. Other clinical entities that can cause an increase in absolute height or accelerated height velocity include obesity, Marfan syndrome, homocystinuria, total lipodystrophy, neurofibromatosis, and chromosomal abnormalities such as Klinefelter syndrome, and 48XXYY and 47XYY syndromes.