RT Book, Section A1 Fisher, Delbert A. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 7053333 T1 Chapter 528. Acquired Hypothyroidism T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=7053333 RD 2024/03/28 AB Hypothyroidism can develop at any age among previously healthy children, although it is more common among girls. Growth retardation is an early sign. Iodine deficiency remains a major cause of hypothyroidism, but the worldwide incidence is decreasing. A high proportion of patients have circulating antithyroid antibodies characterizing an autoimmune process (Hashimoto thyroiditis). Among others, acquired juvenile hypothyroidism can be caused by exposure to goitrogenic agents, thyroid dysgenesis, late onset of hypothyroidism caused by an inborn error of thyroidal biosynthesis, acquired hypothalamic or pituitary hypothyroidism, or endemic factors.1-6 As part of the clinical history, the physician should inquire about potential intake, or contact through environmental or familial occupational” sources, with the known potential goitrogens listed in Table 527-2.