RT Book, Section
A1 Styne, Dennis M.
A1 Cuttler, Leonna
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7054683
T1 Chapter 541. Abnormal Pubertal Development
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7054683
RD 2024/04/24
AB Sexual  precocity  is  the  general  term  for  early  puberty.  Isosexual  precocity  refers  to  a  girl  who  feminizes  or  a  boy  who  virilizes  early.  Central  precocious  puberty  or  true  precocious  puberty  is  a  term  reserved  for  children  with  gonadotropin-releasing  hormone  (GnRH)-dependent  early  puberty  that  follows  the  normal  pubertal  pattern  and  the  normal  control  mechanisms  through  GnRH.  The  only  difference  from  normal  puberty  is  the  earlier  age  at  onset.  Central  precocious  puberty  can  be  idiopathic  or  caused  by  organic  conditions  such  as  a  brain  tumor  or  a  hamartoma  of  the  tuber  cinereum.  GnRH-independent  isosexual  precocity  is  caused  by  excessive  estrogen  secretion  in  girls  or  androgen  secretion  in  boys  from  sources  other  than  the  GnRH-gonadotropin  axis  (such  as  the  gonads,  the  adrenal  glands,  ectopic  human  chorionic  gonadotropin  (hCG)  secretion,  and  exogenous  sources  of  sex  steroids).  Gonadotropins  are  suppressed  by  negative  feedback  in  all  forms  of  GnRH-independent  isosexual  precocity  because  sex  steroid  secretion  is  autonomous.  Contrasexual  (or  heterosexual)  precocity  refers  to  girls  who  virilize  and  boys  who  feminize.