RT Book, Section A1 Weinberg, Samuel A1 Prose, Neil S. A1 Kristal, Leonard SR Print(0) ID 6988322 T1 Section 15. Cutaneous Manifestations of Systemic Disease T2 Color Atlas of Pediatric Dermatology, 4e YR 2008 FD 2008 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-145543-5 LK accesspediatrics.mhmedical.com/content.aspx?aid=6988322 RD 2024/04/20 AB Figure 15-1 illustrates cutaneous involvement of systemic lupus erythematosus (SLE) in the classic butterfly pattern on the face. This macular and intensely erythematous eruption is frequently aggravated by sun exposure and may flare with other symptoms of systemic disease. Figure 15-2 shows the temporary alopecia that is also a hallmark of SLE. This autoimmune disease of unknown etiology affects almost every organ system. The most common findings in the child with SLE are fever, arthralgias, and arthritis. In addition, pleuritis, pericarditis, and central nervous system involvement are frequently seen in children with SLE. Lupus nephritis develops in the vast majority of affected children and may eventually cause renal failure.