RT Book, Section
A1 Weinberg, Samuel
A1 Prose, Neil S.
A1 Kristal, Leonard
SR Print(0)
ID 6989079
T1 Section 27. Miscellaneous Anomalies
T2 Color Atlas of Pediatric Dermatology, 4e
YR 2008
FD 2008
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-145543-5
LK accesspediatrics.mhmedical.com/content.aspx?aid=6989079
RD 2024/09/14
AB Among  the  many  hazards  of  intrauterine  development  and  sojourn  is  failure  at  times  to  achieve  complete  congenital  integrity  of  the  integument.  It  sometimes  happens  that  a  child  is  born  with  a  superficial  erosion,  as  in  Fig.  27-1,  or  an  ulcer,  as  in  Figs.  27-2  and  27-3.  The  vertex  of  the  scalp  is  a  common  place  for  the  phenomenon  to  occur;  the  hands,  face,  and  points  over  bony  prominences  are  also  susceptible.  Aplasia  cutis  congenita  is  frequently  a  benign  event  of  only  cosmetic  importance,  and  in  most  cases  the  etiology  is  not  established.  However,  epidermolysis  bullosa,  placental  infarction,  teratogens,  and  some  chromosome  deletions  and  trisomies  are  occasionally  implicated  as  causes.  A  lesion  may  be  directly  adjacent  to  an  epidermal  nevus  or  nevus  sebaceus,  or  it  may  overlie  a  defect  in  the  bone.  More  significant  underlying  anomalies  are  meningomyeloceles,  spinal  dysraphisms,  and  various  cerebral  malformations.  Hemorrhage  and  secondary  infection  may  occur,  requiring  emergency  treatment.  The  combination  of  aplasia  cutis  congenita  and  distal  limb  reduction  is  an  additional  inherited  disorder.