RT Book, Section
A1 D'Alessandro, Lisa C.A.
A1 Peyvandi, Shabnam
A1 Schachtner, Susan
A1 Goldmuntz, Elizabeth
A2 Gleason, Marie Murphy
A2 Rychik, Jack
A2 Shaddy, Robert
SR Print(0)
ID 56745781
T1 Chapter 4. The Genetics of Abnormal Cardiac Development
T2 Pediatric Practice: Cardiology
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-176320-2
LK accesspediatrics.mhmedical.com/content.aspx?aid=56745781
RD 2024/04/20
AB Congenital  heart  disease  (CHD)  is  the  most  common  major  birth  defect,  and  yet  its  etiology  remains  poorly  understood.  It  is  generally  accepted  that  both  genetic  and  environmental  factors  contribute  to  abnormal  cardiac  development.  With  rapid  advances  in  the  field  of  genetics,  specific  gene  alterations  underlying  named  syndromes  or  groups  of  cardiac  malformations  continue  to  be  identified.  Our  understanding  of  both  positive  and  negative  environmental  influences  also  continues  to  evolve.  Identifying  the  etiology  of  cardiac  malformations  is  important,  as  environmental  changes  can  aid  normal  development  and  information  on  inheritance  patterns  and  recurrence  rates  aids  early  identification  of  at-risk  individuals  and  informs  future  plans  for  individuals  and  families.