RT Book, Section A1 Watchko, Jon F. A1 Lin, Zhili A2 Stevenson, David K. A2 Maisels, M. Jeffrey A2 Watchko, Jon F. SR Print(0) ID 56321101 T1 Chapter 1. Genetics of Neonatal Jaundice T2 Care of the Jaundiced Neonate YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-176289-2 LK accesspediatrics.mhmedical.com/content.aspx?aid=56321101 RD 2024/03/29 AB Neonatal hyperbilirubinemia and resultant jaundice are common,1,2 affecting up to ˜80% of newborns.1 Although generally a benign postnatal transitional phenomenon, a select number of infants develop more significant and potentially hazardous levels of total serum bilirubin (TSB) (Table 1-1)3,4 that may pose a direct threat of brain damage.3,5,6 Numerous factors contribute to the development of hyperbilirubinemia including genes involved in: (i) the production of bilirubin from heme; (ii) the metabolism of bilirubin; and (iii) heritable conditions that may reduce red blood cell (RBC) life span and predispose to hemolysis, thereby increasing the bilirubin load7–17 in neonates. The genetics of neonatal hyperbilirubinemia is the focus of this chapter.