RT Book, Section A1 Bondoc, Alex A1 Tiao, Greg M. A2 Ziegler, Moritz M. A2 Azizkhan, Richard G. A2 Allmen, Daniel von A2 Weber, Thomas R. SR Print(0) ID 1100952828 T1 Chronic Pancreatitis in the Pediatric Population T2 Operative Pediatric Surgery, 2e YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-162723-8 LK accesspediatrics.mhmedical.com/content.aspx?aid=1100952828 RD 2024/10/10 AB An unremitting, deranged inflammatory response characterizes chronic pancreatitis (CP) in children and is modulated by environmental and genetic factors.Unlike adults, the etiology of pediatric CP involves congenital or anatomic variants, genetic mutations, or autoimmune disease.The diagnostic work-up of children suspected to have CP should include sweat chloride assessment, genetic assay for CFTR, SPINK1, and PRSS mutations, endoscopic and/or radiographic imaging, and autoimmune testing.Initial therapy for CP includes treatment for symptoms including pain and endocrine and/or exocrine insufficiency. However, more invasive endoscopic or surgical therapy may be necessary and is often predicated on degrees of ductal obstruction and parenchymal disease.