RT Book, Section
A1 Srivatsa, Abhinash
A1 Majzoub, Joseph A.
A1 Kappy, Michael S.
A2 Kappy, Michael S.
A2 Allen, David B.
A2 Geffner, Mitchell E.
SR Print(0)
ID 1107892950
T1 Posterior Pituitary and Disorders of Water Metabolism
T2 Pediatric Practice: Endocrinology, 2e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 9780071813174
LK accesspediatrics.mhmedical.com/content.aspx?aid=1107892950
RD 2024/04/19
AB Maintenance  of  the  tonicity  of  extracellular  fluids  within  a  very  narrow  range  is  crucial  for  proper  cell  function  because  extracellular  osmolality  regulates  cell  shape,  as  well  as  intracellular  concentrations  of  ions  and  other  osmolytes.1,2  Furthermore,  proper  extracellular  ionic  concentrations  are  necessary  for  the  correct  function  of  ion  channels,  action  potentials,  and  other  modes  of  intercellular  communication.  Normal  blood  tonicity  is  maintained  over  a  10-fold  variation  in  water  intake  by  a  coordinated  interaction  among  the  vasopressin,  thirst,  and  renal  systems.  Dysfunction  in  any  of  these  systems  can  result  in  abnormal  regulation  of  blood  osmolality,  which,  if  not  properly  recognized  and  treated,  may  cause  life-threatening  hyperosmolality  or  hypo-osmolality.