RT Book, Section A1 Connor, Ellen Lancon A1 Egberg, Matthew A2 Kappy, Michael S. A2 Allen, David B. A2 Geffner, Mitchell E. SR Print(0) ID 1102505486 T1 Enteric Hormones T2 Pediatric Practice: Endocrinology, 2e YR 2013 FD 2013 PB McGraw-Hill Education PP New York, NY SN 9780071813174 LK accesspediatrics.mhmedical.com/content.aspx?aid=1102505486 RD 2024/03/28 AB Enteric hormones orchestrate appetite, food-seeking behaviors, intake, physical and chemical digestion, and the absorption of the nutrients, intricately linking the brain, the intestines, and multiple endocrine organs to sustain the energy balance of an organism. In 1902, William Maddox Bayliss and Ernest Henry Starling demonstrated that the gastrointestinal (GI) system is the body’s largest endocrine organ. Their work with secretin establishes roles of the GI system beyond digestion and nutrition and includes systemic signaling between regions of the GI system and the central nervous system (CNS) to coordinate appetite, satiety, digestion, and absorption.