RT Book, Section
A1 Bandyopadhyay, Subhankar
A1 Ugalde, Irma
A2 Stone, C. Keith
A2 Humphries, Roger L.
A2 Drigalla, Dorian
A2 Stephan, Maria
SR Print(0)
ID 1106019661
T1 Shock
T2 CURRENT Diagnosis & Treatment: Pediatric Emergency Medicine
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071799454
LK accesspediatrics.mhmedical.com/content.aspx?aid=1106019661
RD 2024/04/19
AB Any  condition  that  results  in  inadequate  tissue  oxygen  delivery  triggers  an  autonomic  response  in  human  body  to  maintain  homeostasis.  A  cellular  response  to  decreased  oxygen  delivery  activates  cascades  of  physiologic  compensatory  mechanisms  to  maintain  normal  functions.  Therefore,  in  a  state  of  shock,  inadequate  oxygen  delivery  fails  to  meet  cellular  metabolic  demands  and  results  in  global  tissue  hypoperfusion  and  metabolic  acidosis.  Cellular  response  to  decreased  oxygen  delivery  causes  adenosine  triphosophate  (ATP)  depletion,  energy-dependent  ion  pump  dysfunction,  and  loss  of  cell  membrane  integrity.  These  events  lead  to  systemic  lactic  acidosis  with  overpowering  of  various  compensatory  mechanisms  that  progress  to  multiple  organ  failure  and  ultimately  death.