RT Book, Section
A1 Lehman, Joy
A2 Goday, Praveen S.
A2 Mehta, Nilesh M.
SR Print(0)
ID 1105178839
T1 Drug–Nutrient Interactions
T2 Pediatric Critical Care Nutrition
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-179852-5
LK accesspediatrics.mhmedical.com/content.aspx?aid=1105178839
RD 2024/04/25
AB From  the  time  a  fetus  is  viable  through  adolescence,  the  body  is  undergoing  exponential  growth  and  development.  However,  the  development  of  organ  function  and  body  composition  does  not  occur  in  a  linear  fashion.  How  the  body  processes  nutrients  and  medications  from  birth  through  age  2  changes  rapidly.  There  is  also  a  significant  change  as  the  body  begins  the  growth  spurt  through  adolescence.1  Critical  illness,  whether  in  the  setting  of  extreme  prematurity,  sepsis,  or  chronic  illness,  may  significantly  impact  growth  and  development  as  well  as  organ  function.  Electrolyte  abnormalities,  glucose  intolerance,  and  protein  malnutrition  are  common  in  the  pediatric  intensive  care  unit  (PICU)  patient.2  Medications  may  impact  these  changes,  and  likewise  the  organ  function  disruptions  that  occur  in  critical  illness  may  affect  how  the  body  processes  medications.3  When  considering  drug–nutrient  interactions  within  the  PICU  setting,  the  clinician  should  consider  the  physiologic  state  of  the  patient,  as  well  as  the  pharmacokinetic,  pharmacodynamic  and  therapeutic  properties  of  both  medications  and  nutrients.  There  is  a  delicate  balance  between  maintaining  nutritional  and  therapeutic  goals  in  the  PICU  setting,  but  these  should  never  be  considered  mutually  exclusive.