RT Book, Section
A1 Abdulrahman, Eiman
A1 Jain, Shabnam
A2 Schafermeyer, Robert
A2 Tenenbein, Milton
A2 Macias, Charles G.
A2 Sharieff, Ghazala Q.
A2 Yamamoto, Loren G.
SR Print(0)
ID 1105683234
T1 Toxic Shock Syndrome
T2 Strange and Schafermeyer's Pediatric Emergency Medicine, 4e
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-182926-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=1105683234
RD 2024/04/19
AB Toxic  shock  syndrome  (TSS)  is  an  acute,  toxin-mediated  illness  characterized  by  fever,  erythematous  rash,  hypotension,  multi-organ  involvement,  and  desquamation.Most  cases  of  TSS  have  been  associated  with  Staphylococcus  aureus,  However,  Group  A  Streptococcus  (GAS)  can  cause  a  similar  disease  known  as  streptococcal  TSS  (STSS).Menstrual  and  nonmenstrual  cases  of  TSS  are  now  reported  with  almost  equal  frequency.  Predisposing  factors  for  nonmenstrual  TSS  are  surgical  and  nonsurgical  trauma,  burns,  and  postpartum  conditions.  Predisposing  factors  for  STSS  are  varicella,  NSAID  use,  and  deep-seated  GAS  infections.STSS  patients  may  have  severe  pain  and  hyperesthesia  out  of  proportion  to  the  degree  of  skin  involvement.Management  depends  on  prompt  recognition,  identification,  and  removal  of  the  infectious  focus.  In  addition,  antibiotics  and  hemodynamic  support  are  essential.Clindamycin  has  been  recommended  as  the  antibiotic  of  choice  for  both  TSS  and  STSS  (along  with  penicillin  G  for  GAS).TSS  can  mimic  many  common  diseases  and  should  be  considered  in  any  patient  who  has  unexplained  fever,  rash,  and  a  toxic  condition  out  of  proportion  to  local  findings.