RT Book, Section
A1 Gomella, Tricia Lacy
A1 Cunningham, M. Douglas
A1 Eyal, Fabien G.
A1 Tuttle, Deborah J.
SR Print(0)
ID 1107524712
T1 Osteopenia of Prematurity
T2 Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 9780071768016
LK accesspediatrics.mhmedical.com/content.aspx?aid=1107524712
RD 2024/10/10
AB Prematurity  affects  bone  mineralization  and  bone  growth—thus  the  entity  known  as  osteopenia  of  prematurity;  however,  some  authors  use  the  term  “rickets  of  prematurity.”  Normal  bone  is  formed  by  the  deposition  of  minerals,  predominantly  calcium  (Ca+2)  and  phosphorus  (P),  onto  an  organic  matrix  (osteoid)  secreted  by  the  osteoblasts.  Osteoclasts  play  an  important  role  in  bone  resorption  and  remodeling.  Although  osteopenia  and  rickets  result  in  decreased  bone  mineralization  and  may  have  similar  clinical  findings,  they  are  not  identical  processes  and  thus  the  term  “rickets  of  prematurity”  is  not  used  in  this  chapter.  Osteopenia  of  prematurity  is  principally  a  result  of  inadequate  calcium  intake  to  meet  bone  growth  demands.  Rickets,  however,  is  principally  due  to  vitamin  D  deficiency,  but  vitamin  D  supplementation  alone  will  not  resolve  either  osteopenia  or  rickets.  Both  disease  processes  involve  the  utilization  of  calcium,  phosphorous,  and  vitamin  D.