RT Book, Section A1 Gomella, Tricia Lacy A1 Cunningham, M. Douglas A1 Eyal, Fabien G. A1 Tuttle, Deborah J. SR Print(0) ID 1107525091 T1 Spontaneous Intestinal Perforation T2 Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e YR 2013 FD 2013 PB McGraw-Hill Education PP New York, NY SN 9780071768016 LK accesspediatrics.mhmedical.com/content.aspx?aid=1107525091 RD 2023/05/27 AB A spontaneous intestinal perforation (SIP) is a single intestinal perforation typically involving the antimesenteric border of distal ileum, which usually occurs without a defined prodrome in extremely premature infants in the first 1–2 weeks of life. These infants usually have not been fed (or have received minimum feeds). At the area of perforation, focal hemorrhagic necrosis with well-defined margins is observed in contrast to ischemic and coagulative necrosis seen in necrotizing enterocolitis (NEC). The bowel proximal and distal to the perforation appears normal.