RT Book, Section
A1 Gomella, Tricia Lacy
A1 Cunningham, M. Douglas
A1 Eyal, Fabien G.
A1 Tuttle, Deborah J.
SR Print(0)
ID 1107525494
T1 Syphilis
T2 Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 9780071768016
LK accesspediatrics.mhmedical.com/content.aspx?aid=1107525494
RD 2024/04/25
AB Syphilis  is  a  sexually  transmitted  infection  caused  by  Treponema  pallidum,  which  is  a  thin,  motile  spirochete  that  is  extremely  fastidious,  surviving  only  briefly  outside  the  host.  According  to  the  Centers  for  Disease  Control  and  Prevention  (CDC),  a  case  of  congenital  syphilis  (CS)  is  defined  as  illness  in  an  infant  from  whom  lesional,  placental,  umbilical  cord,  or  autopsy  material  specimens  demonstrated  T.  pallidum  by  dark-field  microscopy,  fluorescent  antibody,  or  other  specific  stain;  an  infant  whose  mother  had  untreated  or  inadequately  treated  syphilis  at  delivery  (ie,  any  nonpenicillin  therapy  or  penicillin  administered  <30  days  before  delivery);  or  an  infant  or  child  who  has  a  reactive  treponemal  test  for  syphilis  and  any  of  the  following:  evidence  of  CS  on  physical  examination,  evidence  of  CS  on  radiographs  of  long  bones,  reactive  cerebrospinal  fluid  (CSF)  venereal  disease  research  laboratory  test  (VDRL),  elevated  CSF  cell  count  or  protein  (without  other  causes)  or  a  reactive  fluorescent  treponemal  antibody  absorbed–19S-immunoglobulin  M  (IgM)  antibody  test  or  IgM  enzyme-linked  immunosorbent  assay.  This  definition  includes  infants  who  are  stillborn  to  women  with  untreated  syphilis.