RT Book, Section
A1 Gomella, Tricia Lacy
A1 Cunningham, M. Douglas
A1 Eyal, Fabien G.
A1 Tuttle, Deborah J.
SR Print(0)
ID 1107527774
T1 Hyperbilirubinemia, Conjugated
T2 Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 9780071768016
LK accesspediatrics.mhmedical.com/content.aspx?aid=1107527774
RD 2024/04/16
AB An  infant's  direct  (conjugated)  serum  bilirubin  level  is  3  mg/dL.  The  guidelines  from  the  North  American  Society  for  Pediatric  Gastroenterology,  Hepatology,  and  Nutrition  use  the  following  definition  for  abnormal  direct  bilirubin:  direct  bilirubin  is  >1  mg/dL  if  total  bilirubin  is  20%  of  the  total  if  the  total  bilirubin  is  >5  mg/dL.  Conjugated  hyperbilirubinemia  is  never  normal  or  physiologic.  It  occurs  in  1  in  every  2500  infants.  A  persistent  or  increasing  elevated  direct  bilirubin  is  always  pathologic  and  must  be  evaluated  promptly.  Early  diagnosis  is  urgent  and  treatment  is  essential  because  it  means  a  better  outcome  for  the  infant  and  can  be  potentially  lifesaving  (eg,  biliary  atresia).  The  goal  is  to  complete  the  evaluation  by  45  to  60  days  of  age  (surgery  for  biliary  atresia  has  its  best  outcome  if  performed  before  the  age  of  45–60  days).