RT Book, Section A1 Gomella, Tricia Lacy A1 Cunningham, M. Douglas A1 Eyal, Fabien G. A1 Tuttle, Deborah J. SR Print(0) ID 1107527935 T1 Pneumoperitoneum T2 Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e YR 2013 FD 2013 PB McGraw-Hill Education PP New York, NY SN 9780071768016 LK accesspediatrics.mhmedical.com/content.aspx?aid=1107527935 RD 2024/04/23 AB A pneumoperitoneum (an abnormal collection of free air in the peritoneal cavity) is seen on an abdominal radiograph. The air can be secondary to perforation of the gastrointestinal (GI) tract (most common), from the respiratory tract, or secondary to iatrogenic causes. Necrotizing enterocolitis (NEC) with perforation is the most common cause of a pneumoperitoneum in the neonate. A neonate with a pneumoperitoneum requires immediate evaluation and treatment, as early recognition is important in successful management.