RT Book, Section A1 Gomella, Tricia Lacy A1 Cunningham, M. Douglas A1 Eyal, Fabien G. A1 Tuttle, Deborah J. SR Print(0) ID 1107528441 T1 Coagulation Disorders T2 Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e YR 2013 FD 2013 PB McGraw-Hill Education PP New York, NY SN 9780071768016 LK accesspediatrics.mhmedical.com/content.aspx?aid=1107528441 RD 2024/03/28 AB Bleeding and thrombosis are the 2 extremes of the physiological process of coagulation disorders. Despite major differences in the levels of individual components of the hemostatic system, neonatal coagulation is equal to or somewhat more rapid than that observed in adults. This suggests the existence of a delicately balanced hemostatic system in neonates, with uncommon bleeding or thrombosis in healthy term infants. However, a number of perinatal or neonatal conditions can disrupt this balance and increase the risk for either hemorrhage or thrombus formation. The presence of bleeding in a healthy term or late preterm infant, especially in an infant with a normal platelet count, is strongly suggestive of a congenital bleeding disorder. Hemophilia A and B and von Willebrand disease account for 95–98% of congenital bleeding disorders.