RT Book, Section
A1 Wells, Robert G.
SR Print(0)
ID 1148953335
T1 Metabolic Bone Diseases
T2 Diagnostic Imaging of Infants and Children
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071808392
LK accesspediatrics.mhmedical.com/content.aspx?aid=1148953335
RD 2024/04/18
AB The  growth  plate  is  an  important  site  of  involvement  with  many  of  the  metabolic  bone  diseases.  The  physis,  or  growth  plate,  is  composed  of  chondrocytes  that  are  arranged  in  an  orderly  fashion.  There  are  3  histological  and  functional  zones  of  the  physis.  The  reserve,  or  germinal  cell,  zone  is  adjacent  to  the  epiphysis  and  contains  chondrocyte  precursors.  This  is  an  important  site  of  regulation  of  the  cellular  components  of  the  physis.  The  proliferative  and  hypertrophic  zones  are  characterized  by  the  presence  of  chondrocytes  that  are  organized  into  columns.  The  hypertrophic  zone  is  subdivided  into  zones  of  maturation  (columns  of  cartilage  cells),  degeneration,  and  provisional  calcification.  The  transition  between  cartilage  and  bone  occurs  at  the  zone  of  provisional  calcification  and  adjacent  portion  of  the  metaphysis.  Metaphyseal  vessels  invade  chondrocytes  in  the  portion  of  the  hypertrophic  zone  closest  to  the  metaphysis.  Mineralization  of  the  longitudinal  cartilaginous  septa  of  the  hypertrophic  zone  with  hydroxyapatite  crystal  forms  a  dense  but  fragile  layer,  the  zone  of  provisional  calcification.