RT Book, Section
A1 Adamkin, David H.
A2 Stevenson, David K.
A2 Cohen, Ronald S.
A2 Sunshine, Philip
SR Print(0)
ID 1109791717
T1 Parenteral Nutrition
T2 Neonatology: Clinical Practice and Procedures
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071763769
LK accesspediatrics.mhmedical.com/content.aspx?aid=1109791717
RD 2024/09/18
AB Total  parenteral  nutrition  (TPN)  as  used  today  in  the  neonatal  intensive  care  unit  (NICU)  became  a  part  of  modern  medicine  in  the  late  1960s.  Dudrick  et  al,  in  groundbreaking  work,  first  demonstrated  in  beagle  puppies  the  technique  for  parenterally  administering  nutrients.1  Shortly  thereafter,  Wilmore  and  Dudrick2  reported  the  use  of  this  technique  in  an  infant  who  had  virtually  no  remaining  small  intestine  and  was  totally  dependent  on  these  parenterally  delivered  nutrients  of  glucose,  fibrin  hydrolysate,  minerals,  and  vitamins.  There  were  no  intravenous  fat  emulsions  available,  so  plasma  was  given  in  small  aliquots  to  provide  some  essential  fatty  acids  (EFAs)  and  trace  elements.2  Although  this  historic  patient  did  not  survive,  normal  growth  and  development  was  maintained  for  several  months  solely  on  this  primitive  solution.  By  the  early  1970s,  the  technique  was  being  used  extensively  in  infants  and  children  with  congenital  or  acquired  surgically  correctable  lesions  of  the  gastrointestinal  tract3,4  and  in  infants  with  intractable  diarrhea.4,5  Use  in  the  low  birth  weight  infant  soon  followed.4,6,7