RT Book, Section
A1 Keene, Sarah
A1 Jain, Lucky
A2 Stevenson, David K.
A2 Cohen, Ronald S.
A2 Sunshine, Philip
SR Print(0)
ID 1109793225
T1 Transient Tachypnea of the Newborn
T2 Neonatology: Clinical Practice and Procedures
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071763769
LK accesspediatrics.mhmedical.com/content.aspx?aid=1109793225
RD 2024/04/23
AB Transient  tachypnea  of  the  newborn  (TTN)  was  the  name  given  by  Mary  Ellen  Avery  in  1966  to  describe  a  similar  clinical  presentation  in  a  group  of  8  neonates  with:  marked  tachypnea  on  the  first  day  of  life  (80–140  breaths/minute),  mild  cyanosis,  mild  work  of  breathing,  no  evidence  of  infection,  similar  chest  x-ray  findings,  and  resolution  by  2  to  5  days.1  It  was  also  known  as  type  II  respiratory  distress  in  the  early  years  in  an  effort  to  differentiate  it  from  the  better-known  respiratory  distress  syndrome  (RDS).  It  is  the  most  common  cause  of  respiratory  distress  in  the  term  infant  and  a  frequent  reason  for  admission  to  the  neonatal  intensive  care  unit  (NICU).2,3  TTN  results  from  a  failure  of  the  normal  transition  from  placental  gas  exchange  in  utero  to  pulmonary  gas  exchange  and  breathing.  The  primary  mechanism  causing  TTN  is  delayed  resorption  of  fetal  lung  fluid,  a  complex  process  that  is  now  understood  to  begin  several  days  before  spontaneous  delivery.4,5  Although  our  understanding  of  the  processes  involved  in  the  clearance  of  fetal  lung  fluid  has  increased,  the  clinical  picture  has  remained  much  the  same  as  described  in  1966  (Table  24-1).