RT Book, Section
A1 Sperling, Mark A.
A1 Menon, Ram
A2 Stevenson, David K.
A2 Cohen, Ronald S.
A2 Sunshine, Philip
SR Print(0)
ID 1109795410
T1 Hypoglycemia in the Newborn
T2 Neonatology: Clinical Practice and Procedures
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071763769
LK accesspediatrics.mhmedical.com/content.aspx?aid=1109795410
RD 2024/04/19
AB This  chapter  outlines  the  epidemiology,  etiology,  pathophysiology,  differential  diagnosis,  and  management  approach  to  the  neonate  with  hypoglycemia,  here  defined  as  40  mg/dL  or  less  (≤2.2  mmol,  the  fifth  percentile  for  age)  during  the  first  2  days  of  life  and  50  mg/dL  or  less  (≤2.8  mmol)  of  whole  blood  glucose  thereafter,  with  or  without  suggestive  symptoms.  Note  that  plasma  glucose  concentration  is  about  10%–15%  greater  than  whole  blood  glucose  concentration,  so  criteria  for  hypoglycemia  based  on  plasma  glucose  measurements  must  be  appropriately  adjusted  to  be  greater.  Recent  advances  in  our  understanding  of  the  biochemistry,  physiology,  and  molecular  biology  regulating  prenatal  and  postnatal  glucose  homeostasis  combine  to  provide  a  rational  basis  for  defining,  identifying,  diagnosing,  and  treating  hypoglycemia  in  the  newborn  to  enable  normal  neurodevelopment.1,  2  These  considerations  provide  a  systematic  approach  to  the  problem  of  neonatal  hypoglycemia  and  argue  for  glucose  measurements  to  become  part  of  routine  care  in  all  neonates  prior  to  discharge  from  the  newborn  nursery  and  in  all  sick  neonates  even  after  discharge  from  the  newborn  nursery.