RT Book, Section
A1 Lewis, David B.
A2 Stevenson, David K.
A2 Cohen, Ronald S.
A2 Sunshine, Philip
SR Print(0)
ID 1109795819
T1 Ontogeny of the Immune System
T2 Neonatology: Clinical Practice and Procedures
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071763769
LK accesspediatrics.mhmedical.com/content.aspx?aid=1109795819
RD 2024/04/20
AB The  fetus  and  neonate  are  more  vulnerable  than  older  children  and  adults  to  severe  infection  with  pathogens,  including  pyogenic  bacteria,  fungi,  viruses,  and  intracellular  protozoa.1  Although  this  vulnerability  indicates  substantial  limitations  in  innate  and  adaptive  immunity  in  prenatal  and  early  postnatal  life,  the  mechanistic  basis  for  these  is  only  partially  understood.  Hematopoietic  stem  cell  transplantation  also  provides  compelling  evidence  for  impairment  of  neonatal  T-cell  and  natural  killer  (NK)  cell  immunity:  Allogeneic  hematopoietic  cell  transplantation  with  cord  blood  is  associated  with  a  significantly  lower  risk  of  acute  graft-vs-host  disease—a  disease  that  is  mainly  mediated  by  donor-derived  naïve  T  cells—compared  to  bone  marrow  and  peripheral  blood  transplants  containing  adult  T  cells.2