RT Book, Section
A1 Lau, Yu-Lung
A1 Lee, Pamela
A2 Stevenson, David K.
A2 Cohen, Ronald S.
A2 Sunshine, Philip
SR Print(0)
ID 1109796020
T1 Phagocytic Disorder
T2 Neonatology: Clinical Practice and Procedures
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071763769
LK accesspediatrics.mhmedical.com/content.aspx?aid=1109796020
RD 2024/04/20
AB Phagocytosis  is  the  process  by  which  leukocytes  internalize  particles  larger  than  1  μm,  such  as  microbes,  apoptotic  cells,  and  chemical  substances.1  It  is  an  essential  component  of  the  innate  and  adaptive  immune  response,  as  well  as  tissue  remodeling  and  repair.2  Neutrophils,  macrophages,  and  dendritic  cells  are  professional  phagocytes  that  are  derived  from  the  common  myeloid  progenitor.3  As  the  invading  microbes  cross  the  skin  and  mucosal  barrier  and  enter  the  tissue,  they  are  recognized  by  resident  macrophages  and  dendritic  cells  through  germline-encoded  pattern  recognition  receptors.  The  release  of  proinflammatory  cytokines  activates  local  endothelial  and  epithelial  cells,  which  express  chemoattractants  and  adhesion  molecules.  Circulating  neutrophils  adhere  to  the  endothelium  and  migrate  through  the  endothelial  lining  into  the  tissues.4,  5