RT Book, Section
A1 Gutierrez, Kathleen
A2 Stevenson, David K.
A2 Cohen, Ronald S.
A2 Sunshine, Philip
SR Print(0)
ID 1117368394
T1 Herpes Simplex Virus
T2 Neonatology: Clinical Practice and Procedures
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071763769
LK accesspediatrics.mhmedical.com/content.aspx?aid=1117368394
RD 2024/04/20
AB Neonatal  herpes  simplex  virus  (HSV)  infection  refers  to  any  HSV  infection  occurring  in  infants  within  the  first  28  days  of  life.  Most  infants  present  with  symptoms  within  the  first  2–3  weeks  of  life,  and  some  cases  are  recognized  as  late  as  4–6  weeks  of  age  (rare  cases  recognized  up  until  8  weeks  of  age).  Both  HSV-1  and  HSV-2  cause  serious  infection  in  the  neonate.  If  infection  is  unrecognized  and  untreated,  50%  of  infants  with  central  nervous  system  (CNS)  HSV  disease  and  85%  of  infants  with  disseminated  HSV  infection  die  by  1  year  of  age.1  Advances  in  the  diagnosis  and  treatment  of  neonatal  HSV  infection  since  the  mid-1980s  have  improved  the  outcomes  of  infected  infants.2  Despite  advances  in  care,  there  is  no  evidence  that  the  incidence  of  infection  has  decreased.  Delay  in  diagnosis  persists,  and  some  infants  who  survive  infection  suffer  devastating  long-term  sequelae.2