RT Book, Section
A1 Aziz, Natali
A1 Norton, Mary E.
A2 Stevenson, David K.
A2 Cohen, Ronald S.
A2 Sunshine, Philip
SR Print(0)
ID 1109796506
T1 Parvovirus B19 Infection
T2 Neonatology: Clinical Practice and Procedures
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071763769
LK accesspediatrics.mhmedical.com/content.aspx?aid=1109796506
RD 2024/04/19
AB Human  parvovirus  B19,  a  single-stranded  DNA  virus,  is  a  member  of  the  erythrovirus  genus  within  the  Parvoviridae  family  and  the  only  erythrovirus  that  is  a  pathogen  in  humans.1  Human  parvovirus  was  first  identified  by  electron  microscopy  in  1975  and  was  associated  with  clinical  disease  approximately  a  decade  later.2  It  is  the  etiologic  organism  that  manifests  clinically  as  erythema  infectiosum  (fifth  disease),  a  common  childhood  viral  exanthem.  In  immunocompetent  adults,  infection  with  B19  is  generally  asymptomatic  or  mild.  It  is  most  commonly  transmitted  through  respiratory  droplets,  and  primary  B19  infection  in  pregnant  women  can  also  result  in  vertical  transmission  to  the  fetus.  Although  most  commonly  asymptomatic  for  both  mother  and  fetus,  in  some  cases  primary  or  acute  infection  in  pregnancy  may  lead  to  adverse  perinatal  outcomes,  including  spontaneous  abortion,  hydrops  fetalis,  and  fetal  demise.