RT Book, Section A1 Tollefson, Megha M. A1 Benjamin, Latanya T. A2 Stevenson, David K. A2 Cohen, Ronald S. A2 Sunshine, Philip SR Print(0) ID 1109797497 T1 Desquamating and Hyperkeratotic Disorders in the Neonatal Period T2 Neonatology: Clinical Practice and Procedures YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071763769 LK accesspediatrics.mhmedical.com/content.aspx?aid=1109797497 RD 2023/10/03 AB In the neonatal period, disorders may sometimes present with hyperkeratosis and desquamation of the skin. The differential diagnosis for hyperkeratosis and desquamation in the neonatal period is broad and includes infectious, genetic, inflammatory, immunodeficiency, and metabolic causes. Rarely, these disorders may also present with erythroderma, or generalized skin erythema affecting at least 90% of the body surface.1 Scaling is a commonly associated symptom of erythroderma. Although the frequency of hyperkeratotic and desquamating disorders in the newborn period is unknown, the incidence of neonatal erythroderma has been estimated2 to be 0.11%.