Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Agarwal A. Agarwal A Agarwal, Arnav. Global and regional estimates of the contribution of herpes simplex virus type 2 infection to HIV incidence. 2 Minute Medicine, 17 December 2019. McGraw-Hill, 2019. AccessPediatrics. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=514974§ionid=234750603APA Citation Agarwal A. Agarwal A Agarwal, Arnav. (2019). Global and regional estimates of the contribution of herpes simplex virus type 2 infection to hiv incidence. (2019). 2 minute medicine. McGraw-Hill. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=514974§ionid=234750603.MLA Citation Agarwal A. Agarwal A Agarwal, Arnav. "Global and regional estimates of the contribution of herpes simplex virus type 2 infection to HIV incidence." 2 Minute Medicine McGraw-Hill, 2019, https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=514974§ionid=234750603. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Top Global and regional estimates of the contribution of herpes simplex virus type 2 infection to HIV incidence by Arnav Agarwal Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Herpes simplex virus type 2 (HSV-2) infections significantly contribute to the global burden of sexually-acquired HIV infections. +Evidence Rating Level: 2 (Good) +There is a known strong biological association between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus (HIV) acquisition, transmissibility, and disease severity. This analysis provides the first global and regional-level analysis of population attributable fractions (PAFs) and incidence of HIV infections attributable to HSV-2 infection, with subgroup analyses for female sex workers (FSWs) and men who have sex with men (MSM). Classic epidemiological statistics of polytomous exposure to estimate global and regional PAF and incident HIV infections by age, sex and timing, with pooled adjusted relative risk estimates from systematic review data were used to analyze the association of HSV-2 infection on HIV acquisition. Analyses revealed that 420,000 (95% CI 317,000 to 546,000; PAF 29.6% [95% CI 22.9 to 37.1]) of 1.4 million sexually-acquired adult HIV infections in 2016 were attributable to HSV-2 infections. The largest contribution of HSV-2 infections was evident in the African region, among women, those aged 25 to 49 years, and those with established HSV-2 infections. Study findings suggest a significant burden of underlying HSV-2 infections in sexually-transmitted HIV acquisition, with the greatest burden of HSV-2 infections in areas where the infection is most prevalent. +Click to read the study in Lancet Infectious Diseases +©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.