Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Dougherty B, Chan A. Dougherty B, & Chan A Dougherty, Brian, and Alex Chan. Discontinuing Nasal Continuous Positive Airway Pressure in infants ≤32 weeks gestational age. 2 Minute Medicine, 6 November 2020. McGraw-Hill, 2020. AccessPediatrics. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=554743§ionid=251670964APA Citation Dougherty B, Chan A. Dougherty B, & Chan A Dougherty, Brian, and Alex Chan. (2020). Discontinuing nasal continuous positive airway pressure in infants ≤32 weeks gestational age. (2020). 2 minute medicine. McGraw-Hill. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=554743§ionid=251670964.MLA Citation Dougherty B, Chan A. Dougherty B, & Chan A Dougherty, Brian, and Alex Chan. "Discontinuing Nasal Continuous Positive Airway Pressure in infants ≤32 weeks gestational age." 2 Minute Medicine McGraw-Hill, 2020, https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=554743§ionid=251670964. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Top Discontinuing Nasal Continuous Positive Airway Pressure in infants ≤32 weeks gestational age by Brian Dougherty, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Among infants born ≤ 32 weeks gestational age requiring nasal continuous positive airway pressure (NCPAP), a gradual pressure wean to 3 cm H2O versus stopping at the level of approximately 5 cm H2O did not change the total number of days spent on NCPAP. +Evidence Level Rating: 1 (Excellent) +For infants born prematurely, nasal continuous positive airway pressure (NCPAP) is a mainstay of respiratory support that decreases the need for mechanical ventilation, improves outcomes, and minimizes the incidence of bronchopulmonary dysplasia. It is not, however, without risks; NCPAP is associated with an increased risk of nasal septal injury, pneumothorax, and gastric distention, among others. As such, there is a desire to minimize time spent on NCPAP. This randomized controlled trial examined two strategies of stopping NCPAP – gradual pressure weaning to 3 cm H2O (wean cohort) and stopping at the level of approximately 5 cm H2O (control cohort) – among premature infants ≤ 32 weeks gestational age. The primary outcome was the total days of NCPAP, defined as the need for any NCPAP support within a 24-hour period. 116 infants were randomized to the control cohort (mean [SD] age = 28  weeks, 55% male) and 110 infants to the wean cohort (mean [SD] age = 29  weeks, 51% male). It was found that the total number of days on NCPAP did not differ significantly between the control and wean cohorts (median 16 vs. 14 days, p = 0.56). However, the control cohort was nearly twice as likely to fail the first attempt at stopping NCPCP (p = 0.01) and four-times more likely to have two or more failed attempts at stopping (p < 0.01). In a subgroup analysis, grouping infants 23 to 27 and 28 to 32 weeks gestational age, there was again no difference in the primary outcome. Overall, this study demonstrated that stopping NCPAP at 5 cm H2O compared with a gradual pressure wean from 5 to 3 cm H2O had no difference on the total duration of NCPAP therapy among infants ≤ 32 weeks gestational age, though a strategy of gradually weaning pressure significantly decreased the incidence of failure to stop NCPAP. +Click to read the study in the Journal of Pediatrics +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.