Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. Maternal folic acid supplementation associated with stronger child cognitive performance at 11 years of age. 2 Minute Medicine, 17 March 2021. McGraw-Hill, 2021. AccessPediatrics. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=555811§ionid=254660665APA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. (2021). Maternal folic acid supplementation associated with stronger child cognitive performance at 11 years of age. (2021). 2 minute medicine. McGraw-Hill. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=555811§ionid=254660665.MLA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. "Maternal folic acid supplementation associated with stronger child cognitive performance at 11 years of age." 2 Minute Medicine McGraw-Hill, 2021, https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=555811§ionid=254660665. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Maternal folic acid supplementation associated with stronger child cognitive performance at 11 years of age by Jack Lennon, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Children of mothers who supplemented with folic acid (FA) during the second and third trimesters demonstrated greater processing speed at 11 years of age. +2. FA supplementation in later pregnancy resulted in stronger verbal comprehension skills among females. +Evidence Rating Level: 2 (Good) +Folic acid (FA) has been shown to prevent neural tube defects (NTD) when supplementation occurs before and during early pregnancy. This study investigated the benefits of continued FA supplementation through the second and third trimesters and its impact on neurocognitive performance in children. Included participants were followed up at 11 years of age from the randomized trial of Folic Acid Supplementation in the Second and Third Trimesters (FASSTT) in pregnancy. They were randomly assigned to be given 400 μg/day FA or placebo beginning in the 14th gestational week. Cognitive performance was measured with the Wechsler Intelligence Scale for Children in the following domains: Full Scale IQ, Verbal Comprehension, Perceptual Reasoning, Working Memory, and Processing Speed. Magnetoencephalographic (MEG) brain imaging was used to assess neuronal function. Of 119 mother-child pairs in the FASSTT trial, the cognitive performance of 68 children was assessed at the 11-year follow-up. A total of 31 were in the placebo group (M age = 28.1 years, 95% CI 26.6 to 29.6, 52% female) and 37 were in the FA group (M age = 29.7 years, 95% CI 28.5 to 30.8, 59.8% female). Children of mothers in the FA group scored significantly higher on two Processing Speed tests: Symbol Search (mean difference 2.9, 95% CI 0.3 to 5.5, p = 0.03) and Cancellation (mean difference 11.3, 95% CI 2.5 to 20.1, p = 0.04). Verbal Comprehension was higher in the FA group as well, but only for females (mean difference 6.5, 95% CI 1.2 to 11.8, p = 0.03). MEG assessment with a language tasks demonstrated more efficient semantic processing based on increased power at the High Gamma (49-70 Hz, p = 0.04) and Beta (13-30 Hz, p = 0.01) bands in children from the FA group. Overall, this study found that FA supplementation continues to benefit children when undergone in the second and third trimesters, with cognitive abilities proving stronger in multiple domains into the eleventh year of life. +Click to read the study in BMC Medicine +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.