Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission.

1. Doses of recommended non-influenza vaccines administered to children of all age groups decreased significantly in Southern California following the stay-at-home order at the beginning of the COVID-19 pandemic.

2. During the recovery phase of the pandemic, weekly vaccination rates recovered quickly in children younger than 24 months, but remained significantly lower in children 2-18 years old.

Evidence Rating Level: 2 (Good)

Study Rundown:

During the early stages of the COVID-19 pandemic, there was a drastic decline in well-child visits and therefore decreased vaccine administration to children, thus increasing the risk of vaccine-preventable diseases (VPDs). This study sought to describe trends in routine childhood vaccination occurring in the pre-pandemic, stay-at-home, and reopening periods of 2020 in a large cohort of Southern California children, and compared these findings to the corresponding periods in 2019. Both weekly vaccine doses administered as well as measles-containing vaccine administration were significantly lower at the beginning of the stay-at-home order in March 2020 compared to 2019. Decline in vaccination was less severe in children aged <2 years, and vaccination in this age group was quicker to increase back to near pre-pandemic levels. However, vaccination remained lower in older age groups as well as in non-Hispanic Black children. This is likely in part due to focused efforts of healthcare providers to specifically vaccinate the <2 year age group, given the large number of vaccines given during a short time period to these children. These efforts can be expanded to children of all ages and racial groups to increase vaccine uptake and reduce racial disparities. This study is strengthened by its large and diverse sample of children across multiple medical centers in Southern California, but may not reflect trends among children with poorer access to health care and insurance coverage. Overall, these findings raise concern that outbreaks of VPDs may be on the horizon, and efforts should be taken to ensure all children are up-to-date on their routine immunizations.

In-Depth [retrospective cohort]:

This retrospective cohort study gathered data from electronic health records of nearly one million children enrolled in the Kaiser Permanente Southern California (KPSC) integrated healthcare system. Data including weekly routine vaccine doses, measles-containing vaccine doses, and complete vaccination coverage in children of various age groups (0-23 months, 2-6 years, 7-12 years, 13-18 years) were compared between 2019 and 2020. This data was further broken down into the pre-pandemic (January-March), stay-at-home (April-May), and reopening (June-August) periods. All vaccination data collected in all age groups was found to be lower in 2020 compared to 2019. The greatest difference was seen during the stay-at-home order of 2020, with routine doses administered decreasing by 87.6% (95% CI -88.2%, -86.9%) in children aged 13-18 years, 83% (95% CI -83.6,%, -82.4%) in children aged 2-6 years, and 25.2% (95% CI -26.0%, -24.4%) in children aged <2 years. During the reopening period of 2020, vaccination doses administered remained persistently low in older age groups, but recovered to near 2019 levels, being only 5.2% lower (95%CI -6.0%, -4.4%) in children aged <2 years. On the other hand, vaccine coverage declined more immediately and significantly in children <2 years due to shorter vaccination intervals. Measles-containing vaccine doses given followed similar trends to total vaccine doses given, though measles coverage in the youngest age group remained lower at the end of the study period in 2020 compared to in 2019. Of note, researchers also found that recovery of the number of vaccine doses given was lower in non-Hispanic Black children.

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