Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Wang Y, Bhangu A. Wang Y, & Bhangu A Wang, Yidi, and Avneesh Bhangu. Vitamin C supplementation during pregnancy leads to improved airway function in offspring. 2 Minute Medicine, 29 December 2022. McGraw Hill, 2022. AccessPediatrics. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=606263§ionid=274097645APA Citation Wang Y, Bhangu A. Wang Y, & Bhangu A Wang, Yidi, and Avneesh Bhangu. (2022). Vitamin c supplementation during pregnancy leads to improved airway function in offspring. (2022). 2 minute medicine. McGraw Hill. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=606263§ionid=274097645.MLA Citation Wang Y, Bhangu A. Wang Y, & Bhangu A Wang, Yidi, and Avneesh Bhangu. "Vitamin C supplementation during pregnancy leads to improved airway function in offspring." 2 Minute Medicine McGraw Hill, 2022, https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=606263§ionid=274097645. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Annotate Clip Autosuggest Results Vitamin C supplementation during pregnancy leads to improved airway function in offspring by Yidi Wang, Avneesh Bhangu Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. In this multi-center randomized controlled trial, vitamin C supplementation in pregnant smokers was associated with better lung function in offspring at the age of five. +2. Additionally, vitamin C supplementation in pregnant smokers was also associated with decreased occurrence of wheezing in offspring. +Evidence Rating Level: 1 (Excellent) +Exposure to cigarette smoking in utero is a risk factor for impaired fetal lung development, decreased airway function, and development of asthma in the offspring. Supplementation of vitamin C for pregnant smokers has been shown to increase offspring airway function until the age of 12 months. However, the long-term effects of vitamin C supplementation during pregnancy on airway function have not been assessed. +This multi-center randomized control trial conducted in the United States included 251 pregnant patients aged 15 years or older. Participants were current smokers, defined as having smoked ≥1 cigarette in the last week, and were between 13- and 22-weeks’ gestation. Patients were excluded if they had complex medical conditions, were currently incarcerated, or had unstable methods of communication. 125 patients were randomized to receive vitamin C (500mg/d) and 126 received placebo. The primary outcome was forced mid-expiratory flow (FEF25-75) measured by spirometry at age five. Secondary outcomes included forced expiratory volume in 1 second (FEV1) and self-reported or clinically recorded occurrence of wheeze between 4 and 6 years old. +Results demonstrated that at five years old, children of pregnant smokers who received vitamin C had improved airway function, demonstrated by improvements in FEF25-75 and significantly decreased occurrence of wheeze, compared to the placebo group. This study is limited by potential misclassification of wheeze, which was assessed using survey responses from a parent or caretaker. However, the observed clinically important improvements and lack of adverse events associated with vitamin C supplementation after a long follow-up period are high encouraging for the use of vitamin supplementation in pregnant smokers. Further trials to determine the optimal regimen and time of supplementation during initiation is still needed. +Click to read the study in JAMA Pediatrics +©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.