Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Davis R, Chan A. Davis R, & Chan A Davis, Rhianna, and Alex Chan. Early sex-dependent differences observed in metabolic profiles of overweight and adiposity in young children. 2 Minute Medicine, 19 May 2023. McGraw Hill, 2023. AccessPediatrics. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=626711§ionid=278604176APA Citation Davis R, Chan A. Davis R, & Chan A Davis, Rhianna, and Alex Chan. (2023). Early sex-dependent differences observed in metabolic profiles of overweight and adiposity in young children. (2023). 2 minute medicine. McGraw Hill. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=626711§ionid=278604176.MLA Citation Davis R, Chan A. Davis R, & Chan A Davis, Rhianna, and Alex Chan. "Early sex-dependent differences observed in metabolic profiles of overweight and adiposity in young children." 2 Minute Medicine McGraw Hill, 2023, https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=626711§ionid=278604176. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Annotate Clip Autosuggest Results Early sex-dependent differences observed in metabolic profiles of overweight and adiposity in young children by Rhianna Davis, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Childhood overweight/adiposity at age 5 is associated with a specific profile of circulating metabolites, with a relationship that is more pronounced in girls than boys. +Evidence Rating Level: 2 (Good) +Over 340 million children and adolescents are overweight or obese worldwide, with increasing prevalence over time. Childhood obesity is a known risk factor for the development of cardiometabolic disease. Researchers aimed to assess serum metabolites associated with overweight/ obesity in childhood. They used data from the Canadian-based CHILD Cohort Study. Metabolite profiling was conducted for children at age 5 (n = 900) via multisegment injection-capillary electrophoresis-mass spectrometry. 45% of participants were female and 55% were male. They assessed the relationship between circulating metabolites and childhood overweight/ adiposity, defined as WHO-standardized body mass index ≥ 85th percentile and waist circumference ≥ 90th percentile, respectively. Data were assessed via multivariable linear and logistic regression, with sex-stratified analysis. The authors adjusted for the multiple confounding variables: nightly sleep hours, screen time, social disadvantage index, maternal education, breastfeeding status at 1 year, diet quality score, and physical activity level. They found that each standard deviation (SD) increment of glutamic acid, threonine, and oxoproline was associated with a 20-28% increased risk of overweight/adiposity, whereas the glutamine/glutamic acid ratio was associated with a 20% decreased risk. These associations were statistically significant in females, but not in males. This study determined that childhood overweight/ adiposity at age 5 is associated with a specific metabolic profile, which is more pronounced in girls than boys. Future research may address whether this metabolic profile is predictive of overweight/ obesity in adulthood. It also may be useful for future investigations of the metabolic pathways that contribute to childhood overweight/ obesity. +Click to read the study in BMC Medicine +©2023 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.