Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Davis R, Chan A. Davis R, & Chan A Davis, Rhianna, and Alex Chan. Maternal deoxynivalenol exposure associated with adverse birth outcomes observed in China. 2 Minute Medicine, 7 September 2023. McGraw Hill, 2023. AccessPediatrics. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=629793§ionid=281352248APA Citation Davis R, Chan A. Davis R, & Chan A Davis, Rhianna, and Alex Chan. (2023). Maternal deoxynivalenol exposure associated with adverse birth outcomes observed in china. (2023). 2 minute medicine. McGraw Hill. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=629793§ionid=281352248.MLA Citation Davis R, Chan A. Davis R, & Chan A Davis, Rhianna, and Alex Chan. "Maternal deoxynivalenol exposure associated with adverse birth outcomes observed in China." 2 Minute Medicine McGraw Hill, 2023, https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=629793§ionid=281352248. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Annotate Clip Autosuggest Results Maternal deoxynivalenol exposure associated with adverse birth outcomes observed in China by Rhianna Davis, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Compared to those consuming below the maximum tolerable daily intake of the mycotoxin deoxynivalenol, those consuming above this threshold were at a greater risk of giving birth to small-for gestational age infants. +Evidence rating level: 1 (Excellent) +Deoxynivalenol (DON) is a mycotoxin found in certain agricultural products, such as wheat and corn. It has been found to cause fetal growth retardation in animals, but its effects have not previously been studied in humans. Researchers aimed to assess the effect of DON consumption on fetal growth. 1538 participants were included in this prospective study via the Tongji Maternal and Child Health Cohort (TMCHC) in Wuhan, China. Liquid chromatography with tandem mass spectrometry were used to measure both total (tDON) and free (fDON) DON in urine during the second trimester, which was then used to infer the daily intake of DON. 35.9% of subjects were found to exceed the provisional maximum daily intake of DON, which is 1 µg/kg bw. After adjusting for confounding variables, greater urinary tDON was inversely associated with birth weight (adjusted β = -22.00 g, 95% CI: -37.11, -6.89). Compared to the lowest third of tDON concentrations, birth weight was decreased by 81.11 g (95% CI: -127.00, -35.23) for the highest third (p <0.001). Compared to those below the maximum tolerable daily intake, those above this threshold had offspring with lower birth weight (β = -79.79 g; 95% CI: -119.09, -40.49) and greater risk of small-for gestational age (SGA) (OR = 1.48; 95% CI: 1.02, 2.15). A limitation of this study is that there may be additional confounding variables that were not adjusted for, such as the consumption of toxins other than DON. Overall, this study suggests that stricter regulations on the levels of DON in food products should be enforced for the protection of fetal health. +Click to read the study in BMC Medicine +©2023 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.