Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Nedaie S, Chan A. Nedaie S, & Chan A Nedaie, Soroush, and Alex Chan. Probiotics not effective in decreasing incidence of acute otitis media in children. 2 Minute Medicine, 20 November 2023. McGraw Hill, 2023. AccessPediatrics. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=643631§ionid=283615316APA Citation Nedaie S, Chan A. Nedaie S, & Chan A Nedaie, Soroush, and Alex Chan. (2023). Probiotics not effective in decreasing incidence of acute otitis media in children. (2023). 2 minute medicine. McGraw Hill. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=643631§ionid=283615316.MLA Citation Nedaie S, Chan A. Nedaie S, & Chan A Nedaie, Soroush, and Alex Chan. "Probiotics not effective in decreasing incidence of acute otitis media in children." 2 Minute Medicine McGraw Hill, 2023, https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=643631§ionid=283615316. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Annotate Clip Autosuggest Results Probiotics not effective in decreasing incidence of acute otitis media in children by Soroush Nedaie, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. This randomized placebo-controlled clinical trial found that the daily use of Streptococcus salivarius K12 probiotics did not decrease the incidence of acute otitis media among children attending day care. +Evidence Rating Level: 1 (Excellent) +AOM is a prevalent infection in children and a major contributor to antibiotic use in children. With the need for novel prevention strategies, this double-blind, randomized, placebo-controlled trial conducted across 50 day care centers in Finland assessed the efficacy of S. salivarius K12 probiotics in preventing AOM among children attending day care. 827 children (mean [SD] age, 4.1 [1.6] years; 47.6% girls) were enrolled and randomized in a 1:1 ratio to receive either the S salivarius K12 probiotic or a placebo for six months. The primary outcome assessed was the incidence of AOM requiring antimicrobial therapy, with 8.2% (34 children) in the probiotic group and 5.8% (24 children) in the placebo group experiencing at least one episode, resulting in a non-significant relative risk of 1.42 ([95% CI, 0.86-2.34]; proportion difference, −2.44% [95% CI −5.94% to 1.09%]; P=.17). The mean time to the first AOM episode did not differ significantly between groups, with 174 days in the S. salivarius group and 176 days in the placebo group (P=.18). Recurrent otitis media (≥3 AOM episodes in 6 months) was also similar between the probiotic (1.0%) and placebo (0.5%) groups (proportion difference, −0.50% [95% CI, −1.81% to 0.84%]; P=.41). Overall, these findings indicate that S. salivarius K12 does not confer a reduction in AOM incidence and highlight the need for continued research into effective AOM primary prevention strategies. +Click to read the study in JAMA Network Open +©2023 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.