Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Pan S, Chan A. Pan S, & Chan A Pan, Simon, and Alex Chan. Tofacitinib may be effective as a treatment of pediatric ulcerative colitis. 2 Minute Medicine, 14 June 2024. McGraw Hill, 2024. AccessPediatrics. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=648908§ionid=287605990APA Citation Pan S, Chan A. Pan S, & Chan A Pan, Simon, and Alex Chan. (2024). Tofacitinib may be effective as a treatment of pediatric ulcerative colitis. [publicationyear2] 2 minute medicine. McGraw Hill. https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=648908§ionid=287605990.MLA Citation Pan S, Chan A. Pan S, & Chan A Pan, Simon, and Alex Chan. "Tofacitinib may be effective as a treatment of pediatric ulcerative colitis." 2 Minute Medicine McGraw Hill, 2024, https://accesspediatrics.mhmedical.com/updatesContent.aspx?gbosid=648908§ionid=287605990. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Annotate Clip Autosuggest Results Tofacitinib may be effective as a treatment of pediatric ulcerative colitis by Simon Pan, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Management of pediatric ulcerative colitis with tofacitinib successfully induced corticosteroid-free remission in 16% of patients at week 8 following treatment. +Evidence Rating Level: 2 (Good) +Tofacitinib, a non-selective inhibitor of Janus kinase (JAK) enzymes, was approved in 2018 for the treatment of moderate to severe ulcerative colitis in adults. However, it has not yet been approved for pediatric patients and there remains a lack of data regarding the efficacy and safety of tofacitinib in pediatric patients with ulcerative colitis. This multicentre, retrospective cohort study therefore sought to investigate the outcomes of the use of tofacitinib in pediatric ulcerative colitis. A total of 101 children were included in the analysis with a median follow-up of 24 weeks (IQR, 16-54 weeks) following initiation of tofacitinib, all of whom had received prior anti-tumour necrosis factor-α agents. The primary outcome was corticosteroid (CS)-free remission at week 8, while secondary outcomes included clinical response at week 8 and CS-free remission at all time points. 16% of patients (n = 16) achieved CS-free remission at week 8 following treatment, while 30% (n = 30) demonstrated clinical response but did not achieve CS-free remission. At week 24, 23% (n = 20) of 88 remaining patients achieved CS-free remission. No serious adverse events related to tofacitinib were reported in any patients. Overall, this study found that tofacitinib may be a safe and effective option in inducing CS-free remission in pediatric patients with ulcerative colitis previously refractory to other treatment modalities. +Click to read the study in Inflammatory Bowel Diseases +©2024 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.